| 13/09/08 | Le Mans Le Tallec 35 | 1-2 | Toulouse Mansare 11, Braaten 18 |
| 13/09/08 | Lyon Juninho 40, 71, Benzema 90(p) | 3-2 | Nice Bamogo 3, Remy 20 |
| 13/09/08 | Monaco Park 25, Nimani N'galou 70 | 2-0 | Lorient |
| 13/09/08 | Rennes Briand 27 | 1-1 | Le Havre Lesage 32 |
| 13/09/08 | Valenciennes Pujol 84(p) | 1-1 | Grenoble Foot 38 Courtois 90 |
| 13/09/08 | Auxerre Lejeune 55 | 1-1 | Nancy Zerka 65 |
| 13/09/08 | Bordeaux Chamakh 25 | 1-1 | Marseille Kone 3 |
| 14/09/08 | Caen Ben Khalfallah 28, Nivet 90 | 2-0 | AS Saint-Etienne |
| 14/09/08 | Sochaux Privat 46 | 1-1 | Lille Michel Bastos 63 |
| 14/09/08 | PSG Kezman 7(p) | 1-0 | FC Nantes |
| 20/09/08 | Toulouse Gignac 6, 63(p) | 2-1 | Sochaux Perquis 68 |
| 20/09/08 | Grenoble Foot 38 | 0-1 | Bordeaux Jussie 80 |
| 20/09/08 | Le Havre | 0-1 | Lyon Ederson 44(p) |
| 20/09/08 | Lille De Melo 4, 90, Hazard 89 | 3-2 | Auxerre Quercia 49, 80 |
| 20/09/08 | Lorient Saifi 35 | 1-1 | Caen Deroin 85 |
| 20/09/08 | FC Nantes Bagayoko 40(p), 54 | 2-0 | Valenciennes |
| 20/09/08 | Nice Fae 2, Remy 29 | 2-2 | Le Mans Hellebuyck 50(o), Lamah 85 |
| 21/09/08 | Nancy | 0-0 | Rennes |
| 21/09/08 | AS Saint-Etienne Dabo 13 | 1-0 | PSG |
| 21/09/08 | Marseille | 0-0 | Monaco |
| 27/09/08 | Auxerre Coulibaly 26, Jelen 48, Kahlenberg 85 | 3-0 | Le Havre |
| 27/09/08 | Caen Savidan 2, Ben Khalfallah 10, Nivet 30 | 3-0 | FC Nantes |
| 27/09/08 | Le Mans Helstad 9 | 1-1 | Marseille Ben Arfa 7 |
| 27/09/08 | Lyon Benzema 31, Fred 35 | 2-1 | Nancy Berenguer 36 |
| 27/09/08 | Rennes Briand 52 | 1-0 | Nice |
| 27/09/08 | Sochaux Erdinc 79 | 1-1 | Lorient Ayew 38 |
| 27/09/08 | PSG | 0-1 | Grenoble Foot 38 Akrour 77 |
| 28/09/08 | Monaco | 0-2 | Lille Cabaye 68, Obraniak 87 |
| 28/09/08 | Valenciennes | 0-1 | Toulouse Gignac 90 |
| 28/09/08 | Bordeaux Cavenaghi 57 | 1-1 | AS Saint-Etienne Payet 26 |
