| 13/09/08 | Hertha BSC Berlin Kacar 57, Cicero 85 | 2-2 | VfL Wolfsburg Ricardo Costa 1, Riether 90 |
| 13/09/08 | BV Borussia Dortmund Subotic 66, Frei 70, 87(p) | 3-3 | Schalke Farfan 19(p), Rafinha 38, Westermann 53 |
| 13/09/08 | Hoffenheim | 0-0 | VfB Stuttgart |
| 13/09/08 | Bremen Diego 75, Frings 80, Sanogo 83 | 3-0 | Energie |
| 13/09/08 | Hamburg Guerrero 37, Olic 51, Petric 70 | 3-2 | Leverkusen Barnetta 4, Helmes 27 |
| 13/09/08 | Köln | 0-3 | Bayern Toni 53, 60, Podolski 90 |
| 14/09/08 | Hannover Huszti 32, 47, Schlaudraff 43, 68, Forssell 85(p) | 5-1 | Mönchengladbach Friend 54 |
| 14/09/08 | Bochum Miecel 22, Pfertzel 26 | 2-0 | Arminia |
| 19/09/08 | Leverkusen Rolfes 5, Helmes 19, 59, 65 | 4-0 | Hannover |
| 20/09/08 | Schalke Ochs 41(o) | 1-0 | Eintracht |
| 20/09/08 | Mönchengladbach | 0-1 | Hertha BSC Berlin Kacar 11 |
| 20/09/08 | Bayern Borowski 71, 85 | 2-5 | Bremen Rosenberg 30, 67, Naldo 45, Ozil 64, Pizarro 69 |
| 20/09/08 | Energie Sorensen 13 | 1-1 | Bochum Yahia 47 |
| 20/09/08 | Arminia Kamper 74, Wichniarek 76 | 2-0 | Köln |
| 21/09/08 | VfL Wolfsburg Dejagah 15, Madlung 23, Grafite 28 | 3-0 | Hamburg |
| 21/09/08 | Hoffenheim Ibisevic 5, 48, Salihovic 25, Carlos Eduardo 67 | 4-1 | BV Borussia Dortmund Subotic 90 |
| 21/09/08 | VfB Stuttgart Khedira 28, Gomez 68, Marica 86 | 3-1 | Karlsruhe Freis 8 |
| 26/09/08 | Köln Mohamad 44 | 1-0 | Schalke |
| 27/09/08 | Bremen Ozil 8, 83, Pizarro 16, Diego 20, Hunt 30 | 5-4 | Hoffenheim Ba 15, Salihovic 36, Ibisevic 61(p), Compper 71 |
| 27/09/08 | Hamburg Petric 11 | 1-0 | Mönchengladbach |
| 27/09/08 | BV Borussia Dortmund Hajnal 11, Felipe Santana 20, Frei 75 | 3-0 | VfB Stuttgart |
| 27/09/08 | Hannover Huszti 23 | 1-0 | Bayern |
| 27/09/08 | Hertha BSC Berlin | 0-1 | Energie Jelic 13 |
| 27/09/08 | Bochum Sestak 79, Kaloglu 80 | 2-3 | Leverkusen Vidal 6, Renato Augusto 21, Helmes 61 |
| 28/09/08 | Eintracht Kohler 87 | 1-1 | Arminia Wichniarek 7 |
| 28/09/08 | Karlsruhe Porcello 52, Freis 77 | 2-1 | VfL Wolfsburg Ricardo Costa 78 |
