| Pos. | Team | GP | W | D | L | GF | GA | +/- | Pts |
|---|---|---|---|---|---|---|---|---|---|
| 1 | Columbus Crew | 21 | 11 | 4 | 6 | 34 | 28 | 6 | 37 |
| 2 | New England Revolution | 21 | 11 | 4 | 6 | 29 | 27 | 2 | 37 |
| 3 | Chicago Fire | 21 | 10 | 5 | 6 | 28 | 16 | 12 | 35 |
| 4 | D.C. United | 21 | 10 | 1 | 10 | 36 | 34 | 2 | 31 |
| 5 | New York Red Bulls | 21 | 8 | 7 | 6 | 28 | 28 | 0 | 31 |
| 6 | Toronto FC | 21 | 7 | 5 | 9 | 22 | 27 | -5 | 26 |
| 7 | Kansas City Wizards | 21 | 6 | 8 | 7 | 22 | 28 | -6 | 26 |
| Pos. | Team | GP | W | D | L | GF | GA | +/- | Pts |
|---|---|---|---|---|---|---|---|---|---|
| 1 | Houston Dynamo | 21 | 8 | 8 | 5 | 29 | 25 | 4 | 32 |
| 2 | Real Salt Lake | 21 | 7 | 6 | 8 | 25 | 27 | -2 | 27 |
| 3 | FC Dallas | 21 | 6 | 8 | 7 | 29 | 27 | 2 | 26 |
| 4 | Colorado Rapids | 21 | 7 | 3 | 11 | 29 | 30 | -1 | 24 |
| 5 | Los Angeles Galaxy | 21 | 6 | 6 | 9 | 40 | 43 | -3 | 24 |
| 6 | Chivas USA | 21 | 6 | 6 | 9 | 26 | 31 | -5 | 24 |
| 7 | San Jose Earthquakes | 21 | 5 | 7 | 9 | 19 | 25 | -6 | 22 |
| 29/08/08 | Real Salt Lake | vs. | Colorado |
| 30/08/08 | San Jose | vs. | Kansas City |
| 30/08/08 | D.C. United | vs. | New York |
| 30/08/08 | New England | vs. | Los Angeles |
| 30/08/08 | CD Chivas USA | vs. | Toronto FC |
| 30/08/08 | FC Dallas | vs. | Columbus |
| 31/08/08 | Houston | vs. | Chicago |
| Player | Team | Goals |
|---|---|---|
| Landon Donovan | Los Angeles Galaxy | 14 |
| Kenny Cooper | FC Dallas | 13 |
| Edson Buddle | Los Angeles Galaxy | 12 |
| Luciano Emilio | D.C. United | 11 |
| Brian Ching | Houston Dynamo | 9 |
| Jaime Moreno | D.C. United | 9 |
| Juan Pablo Angel | New York Red Bulls | 8 |
| Chad Barrett | Toronto FC | 7 |
| Alejandro Moreno | Columbus Crew | 7 |
| Adam Cristman | New England Revolution | 6 |
| Steve Ralston | New England Revolution | 6 |
| Guillermo Barros Schelotto | Columbus Crew | 5 |
| David Beckham | Los Angeles Galaxy | 5 |
| Conor Casey | Colorado Rapids | 5 |
| Jimmy Conrad | Kansas City Wizards | 5 |
